Lambda Light Chain Free Serum Mg Dl

A serum panel using serum free light chain analysis in combination with either serum protein electrophoresis or serum immunofixation has been shown in several studies to be a highly sensitive approach to screening for most plasma cell disorders.

Lambda light chain free serum mg dl.

5 71 to 26 3 mg l lambda free light chains. Serum free light chain measurements for identifying and monitoring patients with nonsecretory multiple myeloma. 3 3 to 19 4 mg l kappa free light chains. 5 7 26 3 mg ml.

It is used to assist in the diagnosis of plasma cell disorders including multiple myeloma primary amyloidosis monoclonal gammopathy of unknown significance mgus. The serum free light chain test can be used to determine light chain levels of disease so patients will want to track their light chain numbers. Extremely high light chains at diagnosis. To assess the importance of baseline values at diagnosis the researchers observed that patients who had exceptionally high serum free light chains sflc over 1000 mg dl had worse overall survival.

Kappa lambda light chains free with ratio the kappa lambda light chains free with ratio serum test measures the amount of kappa and lambda free light chains flcs in the blood and calculates the kappa to lambda ratio. Learn more about kappa and lambda light chains and multiple myeloma. Free light chains ranges. Serum free light chain sflc testing is ordered to help detect diagnose and monitor plasma cell disorders dyscrasias including multiple myeloma primary amyloidosis and related diseases or to monitor the effectiveness of treatment.

Normal test results for free light chains are. Kappa light chain concentration range. Results are given in milligrams per liter mg l. Additional genetic testing of a patient s myeloma cells can be done to determine risk based on common genetic myeloma features.

Special instructions library of pdfs including pertinent information and forms related to the test. Serum free light chains serum kappa 3 3 19 4 mg l serum lambda 5 71 26 3 mg l kappa lambda free 0 26 1 65 kappa lambda 0 37 3 1 free renal impairment β 2 microglobulin b2m 2 7 mg l absolute neutrophil complete blood count cbc with differential white blood cell count 3 9 10 7 x wbc 103 cells µl red blood cell count 4 2 5 9 x 106. Light chains are proteins produced by plasma cells within a plasma cell two light chains and two heavy chains combine to form an immunoglobulin. 9 12 the sensitivity of serum free light chain testing approaches 100 for the diagnosis of light chain myeloma 13 is more than 80 in.

Lambda light chain concentration range. Serum free light chain assay14 pages 11 12 kappa free light chain 0 33 1 94 mg dl lambda free light chain 0 57 2 63 mg dl kappa lambda free light chain ratio 0 26 1 65 24 hour urine analysis 4 15 17 pages 13 14 24 hour urine total protein 229 mg 24 hours m spike urine 500 mg 24 hours for asymptomatic patients urine immunofixation n a. The test measures the levels of specific types of free light chains known as kappa and lambda and also the ratio between the two.